On October 3, 1849, Dr. Joseph E. Snodgrass received the following note:
This is the first verifiable evidence available of Poe's whereabouts since departing Richmond in the early morning of September 27. His intended destination had been Philadelphia, where he was to edit a volume of poetry for Mrs. St. Leon Loud. Dr. Snodgrass found Poe semiconscious and dressed in cheap, ill-fitting clothes so unlike Poe's usual mode of dress that many believe that Poe's own clothing had been stolen. Poe was taken to Washington College Hospital on the afternoon of October 3 and did not regain consciousness until the next morning. For days he passed from delirium to unconsciousness, but never recovered well enough to tell how he had arrived in such a condition. For no known reason he started calling loudly for "Reynolds" on the fourth night.
In the early morning hours of October 7, Poe calmly breathed a simple prayer, "Lord, help my poor soul," and died. His cause of death was ascribed to "congestion of the brain." No autopsy was performed, and the author was buried two days later. In dying under such mysterious circumstances, the father of the detective story has left us with a real-life mystery which Poe scholars, medical professionals, and others have been trying to solve for over 150 years.
The following is a bibliography of some of the theories of Poe's cause of death that have been published over the years: